Searchable abstracts of presentations at key conferences in endocrinology

ea0021s4.2 | Glucocorticoid action in inflammation: new insights into old mechanisms | SFEBES2009

A novel mechanism of glucocorticoids to block autoimmunity

Roth Johannes

Active resolution of inflammation is a previously unrecognized process essential for tissue homeostasis. Monocytes and macrophages may either promote or down-regulate inflammatory reactions depending on their state of activation. The effects of glucocorticoids (GCs), the most widely used immunosuppressive drugs, on monocytes are currently not well defined. By analyzing the GC-induced expression pattern in human monocytes by microarray technology and functional clustering we de...